Wrinkle-Reducing Serums Amazon Shoppers Swear By for Smoothing and Firming

Wrinkles are inevitable and, frankly, a privilege. But it’s completely okay not to love the physical changes that can sometimes appear suddenly with aging. It wasn’t until my late 30s that I noticed gradual changes in my skin’s texture and tone, along with an acceleration of fine lines that were barely noticeable a year earlier

Even with daily use of a hydrating moisturizer and sun protection, your skin may need a little something extra to soften the signs of aging, and any of the top-rated serums listed below can help. Featuring ingredients like retinol, hyaluronic acid, peptides and more, these formulas are shopper favorites for reducing wrinkles, smoothing fine lines, improving texture and leaving skin exceptionally hydrated.

• Best Overall: Estée Lauder Advanced Night Repair ($85)
• Best With Growth Factors: SkinMedica TNS Advanced+ Serum ($295)
• Best For Lifting: RoC Retinol Correxion Deep Wrinkle Serum ($30)
• Best Hydrating: Lancôme Advanced Génifique Youth Activating Concentrate ($60)
• Best For Sensitive Skin: Clinique Smart Clinical Repair Wrinkle Correcting Serum ($80)
• Best Budget: The Ordinary Matrixyl 10% + Hyaluronic Acid ($11)
• Best For Dark Spots: La Roche-Posay Retinol B3 Retinol Serum ($45)
• Best Multi-Use: Exuviance AGE REVERSE+ Total Correct Serum ($98)
• Best For Expression Lines: Filorga Time-Filler Intensive 5XP ($98)
• Best With Retinol: Medik8 Crystal Retinal 6 ($85)

1 / 10

Best Overall

Estée Lauder Advanced Night Repair ($85)

This iconic, deeply hydrating overnight serum is a legend for a reason. With  hyaluronic acid, antioxidants and peptides, it hydrates and protects skin and smooths fine lines while you sleep so you wake to firmer, brighter and plumper skin.

• BUY NOW – $85

2 / 10

Best With Growth Factors

SkinMedica TNS Advanced+ Serum ($295)

This dermatologist-loved serum combines growth factors, peptides, antioxidants and hydrating ingredients to target signs of aging and with regular use, you’ll notice an improvement in deep wrinkles and a firmer, glowing complexion. The growth-factor rich formula also addresses sagging skin, delivering a more lifted appearance over time.

• BUY NOW – $295

3 / 10

Best For Lifting

RoC Retinol Correxion Deep Wrinkle Serum ($30)

Alongside powerful pure RoC retinol, minerals like magnesium, zinc and copper blend together to give skin a hydrated and energetic reset. The result: Skin feels smoother, lifted, tighter and more radiant. In a clinical study, users reported reduced sagging and visibly lifted skin in four weeks; in 12 weeks, a “dramatic reduction in the look of deep wrinkles on face and neck.”

• BUY NOW – $30

4 / 10

Best Hydrating

Lancôme Advanced Génifique Youth Activating Concentrate ($60)

With the dry winter season around the corner, grab this lightweight serum that’s packed with hyaluronic acid, a prebiotic and vitamin C. It protects the skin barrier, seals in moisture and defends against environmental assailants while keeping skin hydrated, plump and smooth.

• BUY NOW – $60

5 / 10

Best For Sensitive Skin

Clinique Smart Clinical Repair Wrinkle Correcting Serum ($80)

Fragrance-free and allergy tested, Clinique’s Smart Clinical Repair Wrinkle Correcting Serum was designed with sensitive skin in mind. It contains encapsulated retinol—a slower-releasing form of the active that minimizes the risk of irritation while still gently resurfacing skin to smooth lines and texture. Other key ingredients include hydrating hyaluronic acid and skin-plumping peptides.

• BUY NOW – $80

6 / 10

Best Budget

The Ordinary Matrixyl 10% + Hyaluronic Acid ($11)

A high-quality serum for less than $12? Say hello to The Ordinary’s Matrixyl 10% + Hyaluronic Acid serum. The water-based serum blends two generations of wrinkle-reducing Matrixyl peptides with hyaluronic acid to soften fine lines and boost hydration overall, leading to a plumper and firmer complexion.

• BUY NOW – $11

7 / 10

Best For Dark Spots

La Roche-Posay Retinol B3 Retinol Serum ($45)

With pure retinol, niacinamide and hyaluronic acid, La Roche Posay’s Retinol B3 Serum helps to boost cell turnover, smooth uneven texture, keep the skin barrier hydrated and diminish blemish marks and dark spots. If you want a brighter, more even-toned complexion with visibly softer fine lines, this French pharmacy staple is a no brainer.

• BUY NOW – $45

8 / 10

Best Multi-Use

Exuviance AGE REVERSE+ Total Correct Serum ($98)

We couldn’t write a list about the best wrinkle serums without this year’s Award-winner for Best Multitasking Serum for Aging Skin. It won the honor because it “tackles just about every aging-skin issue you might ever want to take on, including signs of visible aging including texture, suppleness, laxity, radiance, fine lines and wrinkles, volume, firmness, deep lines, clarity and uneven skin tone,” says our editors.

• BUY NOW – $98

9 / 10

Best For Expression Lines

Filorga Time-Filler Intensive 5XP ($98)

French beauty brand Filorga’s Time-Filler Intensive 5XP is dermatologist-recommended. New York dermatologist Marisa Garshick, MD says, “It contains a neuropeptide complex that helps to smooth the appearance of lines, as well as a moisturizing molecular film which provides hydration and a marine ferment to help firm.”

• BUY NOW – $98

10 / 10

Best With Retinol

Medik8 Crystal Retinal 6 ($85)

Containing 0.06 percent of encapsulated retinaldehyde, Medik8’s Crystal Retinal 6 serum is ideally for skin already acclimated to vitamin A use. (Medik8’s Crystal Retinal line has five progressive strengths; this one is right in the middle.) Retinaldehyde, a stabilized version of retinol, helps stave off irritation while diminishing wrinkles and increasing cell turnover. Hyaluronic acid and vitamin E leave skin supple and nourished.

• BUY NOW – $85